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Infertility in females can be associated with amenorrhea / oligomenorrhea or with apparently normal menstruation. The latter can occur due to luteal phase deficiency which may involve abnormal follicular development, ovulation or luteal function. A variety of clinical causes identified include use of certain medications, systemic disease states and endocrine abnormalities. A couple is considered infertile if they fail to conceive after six months of unprotected intercourse.
(In females, preferred sampling time is Day 2 / Day 3 of the menstrual cycle.)